Biophysical assay for tethered signaling reactions reveals tether-controlled activity for the phosphatase SHP-1

Jesse Goyette, Citlali Solis Salas, Nicola Coker-Gordon, Marcus Bridge, Samuel A. Isaacson, Jun Allard, Omer Dushek

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Source: Crossref

Published: Mar 3, 2017

DOI: 10.1126/sciadv.1601692

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Source abstract

Tethering of the cytoplasmic tyrosine phosphatase SHP-1 to clustered receptors increases its activity 900-fold.

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