Mathematical model of renal interstitial fibrosis
Wenrui Hao, Brad H. Rovin, Avner Friedman
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Source: Crossref
Published: Sep 15, 2014
DOI: 10.1073/pnas.1413970111
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Significance This paper deals with fibrosis of the kidney, a disease caused by inflammation, and so far there has been no way to diagnose and monitor the disease’s progression with noninvasive methods (the only way to determine the disease state is by biopsy, which cannot be frequently repeated). For this reason we developed a mathematical model of progression of renal fibrosis and validated it with biomarkers that were obtained from patients’ urine samples. We then used the model to show how antifibrosis drugs that are currently being developed for nonrenal fibrosis can be used to treat renal fibrosis.
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