Supercritical extraction of phloroglucinol and benzophenone derivatives from Hypericum carinatum : Quantification and mathematical modeling
Francisco M. C. Barros, Flávia C. Silva, Jéssica M. Nunes, Rubem M. F. Vargas, Eduardo Cassel, Gilsane L. von Poser
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Published: Oct 14, 2011
DOI: 10.1002/jssc.201100455
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Abstract The aerial parts of Hypericum carinatum (Guttiferae) were extracted with supercritical carbon dioxide under constant temperature (40, 50 or 60°C) and gradual pressure increase (90, 120, 150 and 200 bar) aiming at the recovery of enriched fractions containing uliginosin B, cariphenone A and cariphenone B, compounds of pharmaceutical interest. The yields of these substances were determined by high‐performance liquid chromatography and compared with those obtained with n ‐hexane maceration. The supercritical‐fluid extraction showed higher selectivity than the conventional solvent extraction method. After defining 40°C and 90 bar as the best conditions to obtain the target compounds, a mathematical model was used for the extraction process and a good correlation was achieved with the experimental data.
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