A mathematical model for tetanus transmission and vaccination

Source abstract

Abstract Tetanus is a severe disease of the nervous system, transmitted through bacteria in the environment. In the absence of medical attention, case fatality rates are extremely high. Despite progress towards maternal and neonatal tetanus elimination targets, tetanus remains a serious public health problem. Routine infant and maternal vaccination have contributed to considerable reduction in cases and deaths from tetanus globally. However, protective immunity wanes over time. To increase duration of protection, the World Health Organization recommends three diphtheria-tetanus-pertussis-containing vaccine booster doses be given in early childhood, childhood, and adolescence. Evidence to support country-level decision-making about the introduction of these booster doses is critical. We have developed a novel age-structured, deterministic compartmental model of tetanus transmission and vaccination. The model is driven by environmental transmission and incorporates interventions like hygiene and safe birth practices to reduce the magnitude of environmental transmission. It explicitly models vaccination, separating each dose of the primary series, booster doses, and maternal vaccination to capture dose-specific effectiveness and duration of protection. The model captures heterogeneous immunity profiles by dose and age, and the cumulative nature of vaccine-derived protection. The immune dynamics follow the patterns described in literature and can replicate seroprevalence studies, although the exact characterisation of immunity in the literature still has gaps. This model presents a substantial advancement on previously published models and is well positioned to inform tailored vaccination strategies to reduce neonatal and non-neonatal tetanus.