The macrophage and its role in inflammation and tissue repair: mathematical and systems biology approaches
Joanne L. Dunster
Source abstract
Macrophages are central to the inflammatory response and its ability to resolve effectively. They are complex cells that adopt a range of subtypes depending on the tissue type and stimulus that they find themselves under. This flexibility allows them to play multiple, sometimes opposing, roles in inflammation and tissue repair. Their central role in the inflammatory process is reflected in macrophage dysfunction being implicated in chronic inflammation and poorly healing wounds. In this study, we discuss recent attempts to model mathematically and computationally the macrophage and how it partakes in the complex processes of inflammation and tissue repair. There are increasing data describing the variety of macrophage phenotypes and their underlying transcriptional programs. Dynamic mathematical and computational models are an ideal way to test biological hypotheses against experimental data and could aid in understanding this multi‐functional cell and its potential role as an attractive therapeutic target for inflammatory conditions and tissue repair. WIREs Syst Biol Med 2016, 8:87–99. doi: 10.1002/wsbm.1320 This article is categorized under: Biological Mechanisms > Cell Fates Models of Systems Properties and Processes > Cellular Models Models of Systems Properties and Processes > Mechanistic Models
Evidence graph
No public relationships recorded yet.
Integrity note: This page is a factual metadata record created by deterministic ingestion. It is not a claim that the work moves a mathematical frontier or has been independently verified.