Mathematical Models for FDG Kinetics in Cancer: A Review
Sara Sommariva, Giacomo Caviglia, Gianmario Sambuceti, Michele Piana
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Source: Crossref
Published: Aug 6, 2021
DOI: 10.3390/metabo11080519
Open original source ↗Source abstract
Compartmental analysis is the mathematical framework for the modelling of tracer kinetics in dynamical Positron Emission Tomography. This paper provides a review of how compartmental models are constructed and numerically optimized. Specific focus is given on the identifiability and sensitivity issues and on the impact of complex physiological conditions on the mathematical properties of the models.
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