Protein structural transitions and their functional role
Martin Karplus, Yi Qin Gao, Jianpeng Ma, Arjan van der Vaart, Wei Yang
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Source: Crossref
Published: Dec 13, 2004
DOI: 10.1098/rsta.2004.1496
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Living cells are a collection of molecular machines which carry out many of the functions essential for the cell's existence, differentiation and reproduction. Most, though not all, of these machines are made up of proteins. Because of their complexity, an understanding of how they work requires a synergistic combination of experimental and theoretical studies. In this paper we outline our studies of two such protein machines. One is GroEL, the chaperone from Escherichia coli , which aids in protein folding; the other is F 1 –ATPase, a motor protein which synthesizes and hydrolyses ATP.
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