Validation in adult Black and White women of the ISS model for estimating insulin sensitivity and beta-cell function from mixed-meal tests
Arthur S. Sherman, Nathan Sala, Anne E. Sumner, Joon Ha, Stephanie T. Chung
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Source: Crossref
Published: Oct 1, 2026
DOI: 10.1152/ajpendo.00397.2025
Open original source ↗Source abstract
We have previously validated a differential equation model (the ISS model) to determine insulin sensitivity and beta-cell function from oral glucose tolerance tests. The ISS model is simpler to use and requires less data than other current models. We have now extended this model of glucose-insulin metabolism for use with mixed-meal tolerance tests; MMTs may be preferred because they are more physiological and closer to what people eat in daily life.
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