Cellular Traction as an Inverse Problem

Source abstract

The evaluation of the traction exerted by a cell on a planar substrate is here considered as an inverse problem: shear stress is calculated on the basis of the measurement of the deformation of the underlying gel layer. The adjoint problem of the direct two‐dimensional plain stress operator is derived by a suitable minimization requirement. The resulting coupled systems of elliptic partial differential equations (the direct and the adjoint problem) are solved by a finite element method and tested against experimental measures of displacement induced by a fibroblast cell’s traction.