Complex bursting dynamics in an embryonic respiratory neuron model

Source abstract

Pre-Bötzinger complex (pre-BötC) network activity within the mammalian brainstem controls the inspiratory phase of the respiratory rhythm. While bursting in pre-BötC neurons during the postnatal period has been extensively studied, less is known regarding inspiratory pacemaker neuron behavior at embryonic stages. Recent data in mouse embryo brainstem slices have revealed the existence of a variety of bursting activity patterns depending on distinct combinations of burst-generating INaP and ICAN conductances. In this work, we consider a model of an isolated embryonic pre-BötC neuron featuring two distinct bursting mechanisms. We use methods of dynamical systems theory, such as phase plane analysis, fast–slow decomposition, and bifurcation analysis, to uncover mechanisms underlying several different types of intrinsic bursting dynamics observed experimentally including several forms of plateau bursts, bursts involving depolarization block, and various combinations of these patterns. Our analysis also yields predictions about how changes in the balance of the two bursting mechanisms contribute to alterations in an inspiratory pacemaker neuron activity during prenatal development.