Reconstructing the Duplication History of Tandemly Repeated Sequences
Olivier Gascuel, Denis Bertrand,, Olivier Elernento
Source record
Source: Crossref
Published: Feb 24, 2005
DOI: 10.1093/oso/9780198566106.003.0008
Open original source ↗Source abstract
Abstract Tandemly repeated sequences can be found in all genomes that have been sequenced so far. However, their evolution is only beginning to be understood. In this chapter, we present state-of-the-art mathematical concepts and approaches for studying tandemly repeated sequences, from an evolutionary perspective. We describe a tandem duplication model for representing the evolution of these sequences, and shows that it has strong biological support. Then, we provide extensive mathematical and combin-atorial characterization of tandem duplication trees and describe several algorithms for inferring tandem duplication trees from aligned and ordered sequences. We finally compare these algorithms using computer simulations and discuss directions for further research.
Evidence graph
No public relationships recorded yet.
Integrity note: This page is a factual metadata record created by deterministic ingestion. It is not a claim that the work moves a mathematical frontier or has been independently verified.