Screening of α -Glucosidase Inhibitory Activity from Some Plants of Apocynaceae, Clusiaceae, Euphorbiaceae, and Rubiaceae
Berna Elya, Katrin Basah, Abdul Mun'im, Wulan Yuliastuti, Anastasia Bangun, Eva Kurnia Septiana
Source abstract
Diabetes mellitus (DM) is recognized as a serious global health problem that is characterized by high blood sugar levels. Type 2 DM is more common in diabetic populations. In this type of DM, inhibition of α -glucosidase is a useful treatment to delay the absorption of glucose after meals. As a megabiodiversity country, Indonesia still has a lot of potential unexploited forests to be developed as a medicine source, including as the α -glucosidase inhibitor. In this study, we determine the α -glucosidase inhibitory activity of 80% ethanol extracts of leaves and twigs of some plants from the Apocynaceae, Clusiaceae, Euphorbiaceae, and Rubiaceae. Inhibitory activity test of the α -glucosidase was performed in vitro using spectrophotometric methods. Compared with the control acarbose (IC 50 117.20 μ g/mL), thirty-seven samples of forty-five were shown to be more potent α -glucosidase inhibitors with IC 50 values in the range 2.33–112.02 μ g/mL.
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