Simulation and mathematical analyses of AC electric field driven apoptosis via microtubule disintegration
Pawan K. Tiwari
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Source: Crossref
Published: Aug 17, 2015
DOI: 10.7567/jjap.54.097301
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Abstract The moderate intensity alternating current electric fields with frequencies ranging between a few tens of kilohertz and a few tens of megahertz, also known as tumor treating fields (TTFs) are utilized as a modality in the electrotherapeutic treatment of the cancer cells. The application of sub-MHz TTF on the cancer cell results in the inducement of higher electric field at the furrow between the daughter cells, and such apoptosis stimulating phenomenon is investigated through the Maxwell two-dimensional (2D) finite element simulations. A furrow distance of the order of size of the nucleus accounts for the intense electric field inducement disintegrating the microtubule via the processes of its surface disruption and tubulin dimer detachment. A simulation and mathematical analyses of the microtubule disintegration mechanism is formulated to ascertain one of the factors causing an apoptosis of the cancer cells, and consequently checking their proliferation.
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