Quantitative Measurements of Motor Function in Alzheimer’s Disease, Frontotemporal Dementia, and Dementia with Lewy Bodies: A Proof-of-Concept Study
Frederikke Jeppesen Kragh, Marie Bruun, Esben Budtz-Jørgensen, Lena Elisabeth Hjermind, Robin Schubert, Ralf Reilmann, Jørgen Erik Nielsen, Steen Gregers Hasselbalch
Source abstract
<b><i>Background:</i></b> This study examines the efficacy of using quantitative measurements of motor dysfunction, compared to clinical ratings, in Alzheimer’s disease (AD), frontotemporal dementia (FTD), and dementia with Lewy bodies (DLB). <b><i>Methods:</i></b> In this cross-sectional study, 49 patients with a diagnosis of AD (<i>n</i> = 17), FTD (<i>n</i> = 19), or DLB (<i>n</i> = 13) were included and underwent cognitive testing, clinical motor evaluation, and quantitative motor tests: pronation/supination hand tapping, grasping and lifting, and finger and foot tapping. <b><i>Results:</i></b> Our results revealed significantly higher Q-Motor values in pronation/supination and in grip lift force assessment in AD, FTD, and DLB compared to healthy controls (HC). Q-Motor values detected significant differences between AD and HC, while clinical ratings did not. <b><i>Conclusion:</i></b> Our results suggest that quantitative measurements provide more objective and sensitive measurements of motor dysfunction in dementia.
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