Ziegler's Cross-Polytope Conjecture (simplicial 0/1-polytopes)
Ziegler proved every simplicial $d$-dimensional 0/1-polytope has at most $2d$ vertices, and asked whether attaining $2d$ vertices forces central symmetry (i.e. a 0/1 cross-polytope). Known true for $d \le 6$; open since ~2000.